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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (4): 339-342.doi: 10.3969/j.issn.1674-5671.2012.04.10

• 循证医学 • 上一篇    下一篇

亚甲基四氢叶酸还原酶A1298C基因多态性与肝细胞性肝癌遗传易感性的Meta分析

  

  1. 广西贵港市妇幼保健院；广西医科大学附属肿瘤医院肝胆外科
  • 出版日期:2012-12-25 发布日期:2013-01-11
  • 通讯作者: 吴飞翔 E-mail:wufxiang@yahoo.com.cn

Meta-analysis of the association between MTHFR A1298C polymorphism and susceptibility to hepatocellular carcinoma

  • Online:2012-12-25 Published:2013-01-11

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摘要： 目的 探讨亚甲基四氢叶酸还原酶（methylenetetrahy drofolate reductase，MTHFR）A1298C基因多态性与肝细胞性肝癌（hepatocellular carcinoma，HCC）遗传易感性的关系。方法 计算机检索PubMed、EMbase和中国学术期刊全文数据库等，收集有关MTHFR基因多态性与HCC遗传易感性的病例-对照研究资料，按照纳入标准选择文献，提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比（OR）为效应指标，对纳入文献进行异质性检验，应用Stata 12.0软件对各研究原始数据进行Meta合并，计算合并效应量OR值及95%可信区间（95%CI）。结果 共纳入6项病例-对照研究，病例组为1 708例，对照组为2 911名。等位基因比较模型（C vs A）：OR（95%CI）=0.95（0.85～1.06），P=0.342；纯合子比较模型（CC vs AA）：OR（95%CI）=0.55（0.38～0.79），P=0.001；隐性模型（CC vs AC/AA）：OR（95%CI）= 0.54（0.38～0.78），P= 0.001。结论 MTHFR A1298C 基因多态位点CC基因型能够降低HCC遗传易感性，为保护基因型。

关键词: 肝肿瘤, 亚甲基四氢叶酸还原酶, A1298C, 基因多态性, 遗传易感性, Meta分析

Abstract: Objective To explore the relationship between the methylenetetrahy drofolate reductase（MTHFR） A1298C polymorphism and susceptibility to hepatocellular carcinoma（HCC）. Methods A preformulated search strategy was used to search the English-and Chinese-language research literature on the association between the MTHFR A1298C polymorphism and HCC.The strength of the association was assessed in terms of odds ratios（ORs） and 95% confidence intervals（CIs），and heterogeneity was evaluated.All analyses were conducted using Stata 12.0. Results A total of six case-control studies involving 1 708 cases and 2 911 controls met the inclusion criteria.Significantly reduced risk of HCC was found in the homozygote comparison（CC vs AA：OR 0.55，95%CI 0.38~0.79，P=0.001） and recessive model（CC vs AC/AA：OR 0.54，95%CI 0.38~0.78，P=0.001）.However，no significant increase or decrease in risk was found in the additive model（C vs A：OR 0.95，95%CI 0.85~1.06，P>0.05）.No publication bias was found using any of the genetic models. Conclusions Genotype CC of MTHFR A1298C may decrease the risk of HCC and may therefore constitute a protective factor for HCC.

Key words: Liver neoplasms, Methylenetetrahy drofolate reductase, A1298C, Genetic polymorphism, Susceptibility, Meta-analysis